Cost-Effectiveness of Pazopanib in Advanced Soft Tissue Sarcoma in the United Kingdom
Joint Authors
Amdahl, Jordan
Manson, Stephanie C.
Isbell, Robert
Chit, Ayman
Diaz, Jose
Lewis, Lily
Delea, Thomas E.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In the phase III PALETTE trial, pazopanib improved progression-free survival (PFS) compared with placebo in patients with advanced/metastatic soft tissue sarcomas (mSTS) who had received prior chemotherapy.
We used a multistate model to estimate expected PFS, overall survival (OS), lifetime STS treatment costs, and quality-adjusted life-years (QALYs) for patients receiving pazopanib, placebo, trabectedin, ifosfamide, or gemcitabine plus docetaxel as second-line mSTS therapies.
The cost-effectiveness of pazopanib was expressed as the incremental costs per QALY gained.
Estimates of PFS/OS, adverse events, and utilities for pazopanib and placebo were from the PALETTE trial.
Estimates of relative effectiveness of the other comparators were from an unadjusted indirect comparison versus pazopanib.
Costs were from published sources.
Pazopanib is estimated to increase QALYs by 0.128 and costs by £7,976 versus placebo; cost per QALY gained with pazopanib versus placebo is estimated to be £62,000.
Compared with the other chemotherapies, pazopanib provides similar QALYs at a lower cost.
Pazopanib may not be cost-effective versus placebo but may be cost-effective versus the most commonly used active treatments, although this conclusion is uncertain.
Given the unmet need for effective treatments for mSTS, pazopanib may be an appropriate alternative to some currently used medications in the United Kingdom.
American Psychological Association (APA)
Amdahl, Jordan& Manson, Stephanie C.& Isbell, Robert& Chit, Ayman& Diaz, Jose& Lewis, Lily…[et al.]. 2014. Cost-Effectiveness of Pazopanib in Advanced Soft Tissue Sarcoma in the United Kingdom. Complexity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047451
Modern Language Association (MLA)
Amdahl, Jordan…[et al.]. Cost-Effectiveness of Pazopanib in Advanced Soft Tissue Sarcoma in the United Kingdom. Complexity Vol. 2014, no. 2014 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1047451
American Medical Association (AMA)
Amdahl, Jordan& Manson, Stephanie C.& Isbell, Robert& Chit, Ayman& Diaz, Jose& Lewis, Lily…[et al.]. Cost-Effectiveness of Pazopanib in Advanced Soft Tissue Sarcoma in the United Kingdom. Complexity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047451