Preoperative Diagnosis of Usual Leiomyoma, Atypical Leiomyoma, and Leiomyosarcoma
Joint Authors
Hayashi, Takuma
Matsuda, M.
Ichimura, T.
Kasai, M.
Murakami, M.
Kawamura, N.
Sumi, T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Uterine smooth muscle tumors (SMTs) are common pelvic tumors in women, and most of them are diagnosed as usual leiomyoma (UL).
Exclusion of malignant disease is important in the management of SMTs.
However, differentiation of SMTs remains difficult.
In this study, we aimed to improve the preoperative diagnosis of SMTs.
We examined 21 ULs, 7 atypical leiomyomas (ALs), and 6 leiomyosarcomas (LMSs), all of which were diagnosed by uterine tumor biopsy.
Immunohistochemical findings (low-molecular-mass polypeptide 2 (LMP2) and Ki-67) and clinical features (serum lactate dehydrogenase level and menopause) were evaluated.
Statistically significant differences in the expression of LMP2 and Ki-67 were observed between UL and AL and between UL and LMS.
The combined LMP2 and Ki-67 score was significantly different between UL and AL, between UL and LMS, and between AL and LMS.
The combined immunohistochemistry and clinical findings score (total score) was also significantly different between pathological types.
The findings of this study suggest that the accuracy of the preoperative diagnosis of SMTs may be improved by using a combination of immunohistochemical and clinical findings.
American Psychological Association (APA)
Matsuda, M.& Ichimura, T.& Kasai, M.& Murakami, M.& Kawamura, N.& Hayashi, Takuma…[et al.]. 2014. Preoperative Diagnosis of Usual Leiomyoma, Atypical Leiomyoma, and Leiomyosarcoma. Complexity،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047452
Modern Language Association (MLA)
Matsuda, M.…[et al.]. Preoperative Diagnosis of Usual Leiomyoma, Atypical Leiomyoma, and Leiomyosarcoma. Complexity Vol. 2014, no. 2014 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1047452
American Medical Association (AMA)
Matsuda, M.& Ichimura, T.& Kasai, M.& Murakami, M.& Kawamura, N.& Hayashi, Takuma…[et al.]. Preoperative Diagnosis of Usual Leiomyoma, Atypical Leiomyoma, and Leiomyosarcoma. Complexity. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047452