Consumptive Coagulopathy in Angiosarcoma: A Recurrent Phenomenon?
Joint Authors
Farid, Mohamad
Ahn, Linda
Brohl, Andrew
Cioffi, Angela
Maki, Robert G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To report the prevalence of consumptive coagulopathy in angiosarcoma patients seen at a single center.
Methods.
We retrospectively reviewed case records of 42 patients diagnosed with angiosarcoma at Mount Sinai Hospital between 2000 and 2013.
Results.
Seven patients (17%) met clinical criteria for disseminated intravascular coagulation (DIC) in absence of concomitant clinical states known to cause coagulopathy or myelosuppression.
In all patients who received systemic antineoplastic therapy with resultant disease response or stability, DIC resolved in tandem with clinical improvement.
DIC recurred at time of disease progression in all cases.
Two patients had bulky disease, defined as diameter of largest single or contiguous tumor mass measuring 5 cm or more.
All patients demonstrated an aggressive clinical course with short duration of disease control and demise within 1 year.
In contrast, evaluation over the same period of 17 epithelioid hemangioendothelioma patients serving as a clinical control group revealed no evidence of DIC.
Conclusion.
Angiosarcomas can be associated with a consumptive coagulopathy arising in tandem with disease activity.
Vigilance for this complication will be needed in the course of often aggressive multimodality therapy.
The potential utility of coagulopathy as a prognostic biomarker will need to be explored in future studies.
American Psychological Association (APA)
Farid, Mohamad& Ahn, Linda& Brohl, Andrew& Cioffi, Angela& Maki, Robert G.. 2014. Consumptive Coagulopathy in Angiosarcoma: A Recurrent Phenomenon?. Complexity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047453
Modern Language Association (MLA)
Farid, Mohamad…[et al.]. Consumptive Coagulopathy in Angiosarcoma: A Recurrent Phenomenon?. Complexity Vol. 2014, no. 2014 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1047453
American Medical Association (AMA)
Farid, Mohamad& Ahn, Linda& Brohl, Andrew& Cioffi, Angela& Maki, Robert G.. Consumptive Coagulopathy in Angiosarcoma: A Recurrent Phenomenon?. Complexity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047453