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Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach
Joint Authors
Régis, Bordet
Auger, Florent
Duriez, Patrick
Martin-Nizard, Françoise
Durieux, Nicolas
Pétrault, Olivier
Source
Schizophrenia Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances.
We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in order to develop a tool for predicting symptoms of the metabolic syndrome.
Fat deposition and liver morphometry were assessed by T1-weighted imaging.
Fatty acid composition and fat accumulations in tissues were determined using MR spectroscopy with and without water suppression, respectively.
Risperidone treatment induced a weight gain accompanied with metabolic disturbances such as hyperglycemic status, an increase in visceral adipose tissue (VAT), and liver fat depositions.
Correlations using Methylene-Water Ratio (MWR) and Polyunsaturated Index (PUI) demonstrated a concomitant increase in the weight gain, VAT and liver fat depositions, and a decrease in the quantity of polyunsaturated fatty acids.
These results were consistent with a hepatic steatosis state.
We evaluated the ability of MR techniques to detect subtle metabolic disorders induced by APDs.
Thus, our model and methodology offer the possibility to investigate APDs side effects in order to improve the health conditions of schizophrenic patients.
American Psychological Association (APA)
Auger, Florent& Duriez, Patrick& Martin-Nizard, Françoise& Durieux, Nicolas& Régis, Bordet& Pétrault, Olivier. 2014. Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach. Schizophrenia Research and Treatment،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047472
Modern Language Association (MLA)
Auger, Florent…[et al.]. Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach. Schizophrenia Research and Treatment No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047472
American Medical Association (AMA)
Auger, Florent& Duriez, Patrick& Martin-Nizard, Françoise& Durieux, Nicolas& Régis, Bordet& Pétrault, Olivier. Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach. Schizophrenia Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047472