![](/images/graphics-bg.png)
Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis
Joint Authors
Hannan, Anthony J.
McGorry, Patrick D.
Murphy, Brendan P.
Pang, Terence Y.
Proffitt, Tina-Marie
McConchie, Mirabel
Kerr, Melissa
Markulev, Connie
O’Donnell, Colin
Berger, Gregor E.
Source
Schizophrenia Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
It has been suggested that atypical antipsychotics confer their effects via brain-derived neurotrophic factor (BDNF).
We investigated the effect of quetiapine on serum levels of BDNF and vascular endothelial growth factor (VEGF) in drug-naive first-episode psychosis subjects.
Methods.
Fifteen patients drawn from a larger study received quetiapine treatment for twelve weeks.
Baseline levels of serum BDNF and VEGF were compared to age- and sex-matched healthy controls and to levels following treatment.
Linear regression analyses were performed to determine the relationship of BDNF and VEGF levels with outcome measures at baseline and week 12.
Results.
The mean serum BDNF level was significantly higher at week 12 compared to baseline and correlated with reductions in Brief Psychiatric Rating Scale (BPRS) and general psychopathology scores.
Changes in serum VEGF levels also correlated significantly with a reduction in BPRS scores, a significant improvement in PANNS positive symptoms scores, and displayed a positive relationship with changes in BDNF levels.
Conclusions.
Our findings suggest that BDNF and VEGF are potential biomarkers for gauging improvement of psychotic symptoms.
This suggests a novel neurotrophic-based mechanism of the drug effects of quetiapine on psychosis.
This is the first report of VEGF perturbation in psychosis.
American Psychological Association (APA)
Murphy, Brendan P.& Pang, Terence Y.& Hannan, Anthony J.& Proffitt, Tina-Marie& McConchie, Mirabel& Kerr, Melissa…[et al.]. 2014. Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis. Schizophrenia Research and Treatment،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047484
Modern Language Association (MLA)
Murphy, Brendan P.…[et al.]. Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis. Schizophrenia Research and Treatment No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047484
American Medical Association (AMA)
Murphy, Brendan P.& Pang, Terence Y.& Hannan, Anthony J.& Proffitt, Tina-Marie& McConchie, Mirabel& Kerr, Melissa…[et al.]. Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis. Schizophrenia Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047484