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Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model
Joint Authors
Delibasi, Tuncay
Beyazyildiz, Emrullah
Pınarlı, Ferda Alpaslan
Beyazyıldız, Özlem
Hekimoğlu, Emine Rümeysa
Acar, Uğur
Demir, Muhammed Necati
Albayrak, Aynur
Kaymaz, Figen
Sobacı, Güngör
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Purpose.
The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats.
Methods.
Rats were divided into two groups just after establishment of DES.
Eye drops containing either bromodeoxyuridine labeled MSCs (n=9) or phosphate buffer solution (n=7) were topically applied once daily for one week.
Schirmer test, break-up time score, ocular surface evaluation tests, and corneal inflammatory index scoring tests were applied to all rats at baseline and after treatment.
All rats were sacrificed after one week for histological and electron microscopic analysis.
Results.
Mean aqueous tear volume and tear film stability were significantly increased in rats treated with MSCs (P<0.05).
Infiltration of bromodeoxyuridine labeled MSCs into the meibomian glands and conjunctival epithelium was observed in MSCs treated rats.
Increased number of secretory granules and number of goblet cells were observed in MSCs treated rats.
Conclusion.
Topical application of MSCs could be a safe and effective method for the treatment of DES and could potentially be used for further clinical research studies.
American Psychological Association (APA)
Beyazyildiz, Emrullah& Pınarlı, Ferda Alpaslan& Beyazyıldız, Özlem& Hekimoğlu, Emine Rümeysa& Acar, Uğur& Demir, Muhammed Necati…[et al.]. 2014. Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model. Stem Cells International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047502
Modern Language Association (MLA)
Beyazyildiz, Emrullah…[et al.]. Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model. Stem Cells International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047502
American Medical Association (AMA)
Beyazyildiz, Emrullah& Pınarlı, Ferda Alpaslan& Beyazyıldız, Özlem& Hekimoğlu, Emine Rümeysa& Acar, Uğur& Demir, Muhammed Necati…[et al.]. Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047502