Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
Joint Authors
Tripathy, Naresh Kumar
Singh, Saurabh Pratap
Nityanand, Soniya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Fatty bone marrow (BM) and defective hematopoiesis are a pathologic hallmark of aplastic anemia (AA).
We have investigated adipogenic and osteogenic potential of BM mesenchymal stem cells (BM-MSC) in 10 AA patients (08 males and 02 females) with median age of 37 years (range: 06 to 79 years) and in the same number of age and sex matched controls.
It was observed that BM-MSC of AA patients had a morphology, phenotype, and osteogenic differentiation potential similar to control subjects but adipocytes differentiated from AA BM-MSC had a higher density and larger size of lipid droplets and they expressed significantly higher levels of adiponectin and FABP4 genes and proteins as compared to control BM-MSC ( P < 0.01 for both).
Thus our data shows that AA BM-MSC have enhanced adipogenicity, which may have an important implication in the pathogenesis of the disease.
American Psychological Association (APA)
Tripathy, Naresh Kumar& Singh, Saurabh Pratap& Nityanand, Soniya. 2014. Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia. Stem Cells International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047503
Modern Language Association (MLA)
Tripathy, Naresh Kumar…[et al.]. Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia. Stem Cells International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047503
American Medical Association (AMA)
Tripathy, Naresh Kumar& Singh, Saurabh Pratap& Nityanand, Soniya. Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047503