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Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
In the vertebrate retina, visual signals are segregated into parallel ON and OFF pathways, which provide information for light increments and decrements.
The segregation is first evident at the level of the ON and OFF bipolar cells in distal retina.
The activity of large populations of ON and OFF bipolar cells is reflected in the b- and d-waves of the diffuse electroretinogram (ERG).
The role of gamma-aminobutyric acid (GABA), acting through ionotropic GABA receptors in shaping the ON and OFF responses in distal retina, is a matter of debate.
This review summarized current knowledge about the types of the GABAergic neurons and ionotropic GABA receptors in the retina as well as the effects of GABA and specific GABAA and GABAC receptor antagonists on the activity of the ON and OFF bipolar cells in both nonmammalian and mammalian retina.
Special emphasis is put on the effects on b- and d-waves of the ERG as a useful tool for assessment of the overall function of distal retinal ON and OFF channels.
The role of GABAergic system in establishing the ON-OFF asymmetry concerning the time course and absolute and relative sensitivity of the ERG responses under different conditions of light adaptation in amphibian retina is also discussed.
American Psychological Association (APA)
Popova, E.. 2014. Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses. Scientifica،Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-1047544
Modern Language Association (MLA)
Popova, E.. Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses. Scientifica No. 2014 (2014), pp.1-23.
https://search.emarefa.net/detail/BIM-1047544
American Medical Association (AMA)
Popova, E.. Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-1047544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047544