Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer
Joint Authors
Romee, Rizwan
Leong, Jeffrey W.
Fehniger, Todd A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity.
Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions.
Here, we review the roles of major cytokines that regulate human NK cell development, survival, and function, including IL-2, IL-12, IL-15, IL-18, and IL-21, and their translation to the clinic as immunotherapy agents.
We highlight a recent development in NK cell biology, the identification of innate NK cell memory, and focus on cytokine-induced memory-like (CIML) NK cells that result from a brief, combined activation with IL-12, IL-15, and IL-18.
This activation results in long lived NK cells that exhibit enhanced functionality when they encounter a secondary stimulation and provides a new approach to enable NK cells for enhanced responsiveness to infection and cancer.
An improved understanding of the cellular and molecular aspects of cytokine-cytokine receptor signals has led to a resurgence of interest in the clinical use of cytokines that sustain and/or activate NK cell antitumor potential.
In the future, such strategies will be combined with negative regulatory signal blockade and enhanced recognition to comprehensively enhance NK cells for immunotherapy.
American Psychological Association (APA)
Romee, Rizwan& Leong, Jeffrey W.& Fehniger, Todd A.. 2014. Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer. Scientifica،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1047547
Modern Language Association (MLA)
Romee, Rizwan…[et al.]. Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer. Scientifica No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1047547
American Medical Association (AMA)
Romee, Rizwan& Leong, Jeffrey W.& Fehniger, Todd A.. Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1047547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047547