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Bcl2 Family Functions as Signaling Target in Nicotine-NNK-Induced Survival of Human Lung Cancer Cells
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer death and has a strong etiological association with cigarette smoking.
Nicotine and nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are two major components in cigarette smoke that significantly contribute to the development of human lung cancer.
Nicotine is able to stimulate survival of both normal human lung epithelial and lung cancer cells.
In contrast to nicotine, NNK is a more potent carcinogen that not only induces single-strand DNA breaks and oxidative DNA damage but also stimulates survival and proliferation of normal lung epithelial and lung cancer cells.
However, the molecular mechanism(s) by which nicotine and NNK promote cell survival, proliferation, and lung tumor development remains elusive.
The fate of cells (i.e., survival or death) is largely decided by the Bcl2 family members.
In the past several years, multiple signaling links between nicotine/NNK and Bcl2 family members have been identified that regulate survival and proliferation.
This review provides a concise, systematic overview of the current understanding of the role of the pro- or antiapoptotic proteins in cigarette smoking, lung cancer development, and treatment resistance.
American Psychological Association (APA)
Deng, Xingming. 2014. Bcl2 Family Functions as Signaling Target in Nicotine-NNK-Induced Survival of Human Lung Cancer Cells. Scientifica،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047549
Modern Language Association (MLA)
Deng, Xingming. Bcl2 Family Functions as Signaling Target in Nicotine-NNK-Induced Survival of Human Lung Cancer Cells. Scientifica No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047549
American Medical Association (AMA)
Deng, Xingming. Bcl2 Family Functions as Signaling Target in Nicotine-NNK-Induced Survival of Human Lung Cancer Cells. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047549