Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies
Joint Authors
Kuivaniemi, Helena
Ryer, Evan J.
Elmore, James R.
Hinterseher, Irene
Smelser, Diane T.
Tromp, Gerard
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta with a diameter of at least 3.0 cm.
AAAs are often asymptomatic and are discovered as incidental findings in imaging studies or when the AAA ruptures leading to a medical emergency.
AAAs are more common in males than females, in individuals of European ancestry, and in those over 65 years of age.
Smoking is the most important environmental risk factor.
In addition, a positive family history of AAA increases the person’s risk for AAA.
Interestingly, diabetes has been shown to be a protective factor for AAA in many large studies.
Hallmarks of AAA pathogenesis include inflammation, vascular smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress.
Autoimmunity may also play a role in AAA development and progression.
In this Outlook paper, we summarize our recent studies on AAA including clinical studies related to surgical repair of AAA and genetic risk factor and large-scale gene expression studies.
We conclude with a discussion on our research projects using large data sets available through electronic medical records and biobanks.
American Psychological Association (APA)
Kuivaniemi, Helena& Ryer, Evan J.& Elmore, James R.& Hinterseher, Irene& Smelser, Diane T.& Tromp, Gerard. 2014. Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies. Scientifica،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047571
Modern Language Association (MLA)
Kuivaniemi, Helena…[et al.]. Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies. Scientifica No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047571
American Medical Association (AMA)
Kuivaniemi, Helena& Ryer, Evan J.& Elmore, James R.& Hinterseher, Irene& Smelser, Diane T.& Tromp, Gerard. Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047571