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The Effect of Adjuvant Zinc Therapy on Recovery from Pneumonia in Hospitalized Children: A Double-Blind Randomized Controlled Trial
Joint Authors
Parsa, Yekta
Qasemzadeh, Mohammad Javad
Fathi, Mahdi
Tashvighi, Maryam
Rahimi, Ebrahim
Yadollah-Damavandi, Soheila
Gharehbeglou, Mohammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objectives.
Pneumonia is one of the common mortality causes in young children.
Some studies have shown beneficial effect of zinc supplements on treatment of pneumonia.
The present study aimed to investigate the effects of short courses of zinc administration on recovery from this disease in hospitalized children.
Methods.
In a parallel Double-Blind Randomized Controlled Trial at Ayatollah Golpaygani Hospital in Qom, 120 children aged 3–60 months with pneumonia were randomly assigned 1 : 1 to receive zinc or placebo (5 mL every 12 hours) along with the common antibiotic treatments until discharge.
Primary outcome was recovery from pneumonia which included the incidence and resolving clinical symptoms and duration of hospitalization.
Results.
The difference between two groups in all clinical symptoms at admittance and the variables affecting the disease such as age and sex were not statistically significant ( P < 0.05 ) at baseline.
Compared to the placebo group, the treatment group showed a statistically significant decrease in duration of clinical symptoms ( P = 0.044 ) and hospitalization ( P = 0.004 ).
Conclusions.
Supplemental administration of zinc can expedite the healing process and results in faster resolution of clinical symptoms in children with pneumonia.
In general, zinc administration, along with common antibiotic treatments, is recommended in this group of children.
It can also reduce the drug resistance caused by multiple antibiotic therapies.
This trial is approved by Medical Ethic Committee of Islamic Azad University in Iran (ID Number: 8579622-Q).
This study is also registered in AEARCTR (The American Economic Association's Registry for Randomized Controlled Trials).
This trial is registered with RCT ID: AEARCTR-0000187.
American Psychological Association (APA)
Qasemzadeh, Mohammad Javad& Fathi, Mahdi& Tashvighi, Maryam& Gharehbeglou, Mohammad& Yadollah-Damavandi, Soheila& Parsa, Yekta…[et al.]. 2014. The Effect of Adjuvant Zinc Therapy on Recovery from Pneumonia in Hospitalized Children: A Double-Blind Randomized Controlled Trial. Scientifica،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1047581
Modern Language Association (MLA)
Qasemzadeh, Mohammad Javad…[et al.]. The Effect of Adjuvant Zinc Therapy on Recovery from Pneumonia in Hospitalized Children: A Double-Blind Randomized Controlled Trial. Scientifica No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1047581
American Medical Association (AMA)
Qasemzadeh, Mohammad Javad& Fathi, Mahdi& Tashvighi, Maryam& Gharehbeglou, Mohammad& Yadollah-Damavandi, Soheila& Parsa, Yekta…[et al.]. The Effect of Adjuvant Zinc Therapy on Recovery from Pneumonia in Hospitalized Children: A Double-Blind Randomized Controlled Trial. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1047581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047581