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Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells
Joint Authors
Mahadimane, Periyapatna Vishwaprakash
Vasudev, Venkateshaiah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In order to investigate the presence of adaptive response in cancerous cells, two monofunctional alkylating agents, namely, ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS), were employed to treat Ehrlich ascites carcinoma (EAC) cells in vivo.
Conditioning dose of 80 mg/kg body weight of EMS or 50 mg/kg body weight of MMS and challenging dose of 240 mg/kg body weight of EMS or 150 mg/kg body weight of MMS were selected by pilot toxicity studies.
Conditioned EAC cells when challenged after 8 h time lag resulted in significant reduction in chromosomal aberrations compared to challenging dose of respective agents.
As has been proved in earlier studies with normal organisms, even in cancerous cells (EAC), there is presence of adaptive response to methylating and ethylating agents.
Furthermore, it is also interesting to note in the present studies that the methylating agent, MMS, is a stronger inducer of the adaptive response than the ethylating agent, EMS.
American Psychological Association (APA)
Mahadimane, Periyapatna Vishwaprakash& Vasudev, Venkateshaiah. 2014. Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047582
Modern Language Association (MLA)
Mahadimane, Periyapatna Vishwaprakash& Vasudev, Venkateshaiah. Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047582
American Medical Association (AMA)
Mahadimane, Periyapatna Vishwaprakash& Vasudev, Venkateshaiah. Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047582