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Therapy of Hypoparathyroidism by Replacement with Parathyroid Hormone
Joint Authors
Underbjerg, Line
Sikjaer, Tanja
Rejnmark, Lars
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypoparathyroidism (HypoPT) is a state of hypocalcemia due to inappropriate low levels of parathyroid hormone (PTH).
HypoPT is normally treated by calcium supplements and activated vitamin D analogues.
Although plasma calcium is normalized in response to conventional therapy, quality of life (QoL) seems impaired and patients are at increased risk of renal complications.
A number of studies have suggested subcutaneous injections with PTH as an alternative therapy.
By replacement with the missing hormone, urinary calcium may be lowered and QoL may improve.
PTH replacement therapy (PTH-RT) possesses, nevertheless, a number of challenges.
If PTH is injected only once a day, fluctuations in calcium levels may occur resulting in hypercalcemia in the hours following an injection.
Twice-a-day injections seem to cause less fluctuation in plasma calcium but do stimulate bone turnover to above normal.
Most recently, continuous delivery of PTH by pump has appeared as a feasible alternative to injections.
Plasma calcium levels do not fluctuate, urinary calcium is lowered, and bone turnover is only stimulated modestly (into the normal range).
Further studies are needed to assess the long-term effects.
If beneficial, it seems likely that standard treatment of HypoPT in the future will change into replacement therapy with the missing hormone.
American Psychological Association (APA)
Rejnmark, Lars& Underbjerg, Line& Sikjaer, Tanja. 2014. Therapy of Hypoparathyroidism by Replacement with Parathyroid Hormone. Scientifica،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047589
Modern Language Association (MLA)
Rejnmark, Lars…[et al.]. Therapy of Hypoparathyroidism by Replacement with Parathyroid Hormone. Scientifica No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047589
American Medical Association (AMA)
Rejnmark, Lars& Underbjerg, Line& Sikjaer, Tanja. Therapy of Hypoparathyroidism by Replacement with Parathyroid Hormone. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047589