Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
Joint Authors
Vijayan, Madhuvanthi
Hahm, Bumsuk
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Viruses attempt to create a distinctive cellular environment to favor viral replication and spread.
Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections.
While sphingolipids such as sphingomyelin and ceramide were reported to influence the entry step of several viruses, sphingolipid-metabolizing enzymes could directly alter viral replication processes.
Influenza virus was shown to increase the level of sphingosine kinase (SK) 1 to promote virus propagation.
The mechanism involves regulation of intracellular signaling pathways, leading to the amplification of influenza viral RNA synthesis and nuclear export of viral ribonucleoprotein (RNP) complex.
However, bovine viral diarrhea virus inhibits SK1 to enhance the efficacy of virus replication, demonstrating the presence of virus-specific strategies for modulation of the sphingolipid system.
Therefore, investigating the sphingolipid metabolism and signaling in the context of virus replication could help us design innovative therapeutic approaches to improve human health.
American Psychological Association (APA)
Vijayan, Madhuvanthi& Hahm, Bumsuk. 2014. Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System. Scientifica،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047591
Modern Language Association (MLA)
Vijayan, Madhuvanthi& Hahm, Bumsuk. Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System. Scientifica No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047591
American Medical Association (AMA)
Vijayan, Madhuvanthi& Hahm, Bumsuk. Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047591