![](/images/graphics-bg.png)
Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Macrophages are on the front line of host defense.
They possess an array of germline-encoded pattern recognition receptors/sensors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and which activate downstream effectors/pathways to help mediate innate immune responses and host defense.
Innate immune responses include the rapid induction of transcriptional networks that trigger the production of cytokines, chemokines, and cytotoxic molecules; the mobilization of cells including neutrophils and other leukocytes; the engulfment of pathogens by phagocytosis and their delivery to lysosome for degradation; and the induction of autophagy.
Autophagy is a catabolic process that normally maintains cellular homeostasis in a lysosome-dependent manner, but it also functions as a cytoprotective response that intersects with a variety of general stress-response pathways.
This review focuses on the intimately linked molecular mechanisms that help govern the autophagic pathway and macrophage innate immune responses.
American Psychological Association (APA)
Vural, Ali& Kehrl, John H.. 2014. Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection. Scientifica،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047596
Modern Language Association (MLA)
Vural, Ali& Kehrl, John H.. Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection. Scientifica No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047596
American Medical Association (AMA)
Vural, Ali& Kehrl, John H.. Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047596