Regulation of TGF-β Signal Transduction

Abstract EN

Transforming growth factor-β (TGF-β) signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity, and migration.

TGF-β signaling can be mediated by Smad proteins or other signaling proteins such as MAP kinases and Akt.

TGF-β signaling is tightly regulated at different levels along the pathways to ensure its proper physiological functions in different cells and tissues.

Deregulation of TGF-β signaling has been associated with various kinds of diseases, such as cancer and tissue fibrosis.

This paper focuses on our recent work on regulation of TGF-β signaling.