XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis
Joint Authors
Bai, Xiao-Hui
Cho, Hae-Ra
Moodley, Serisha
Liu, Mingyao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several adaptor proteins have previously been shown to play an important role in the promotion of tumourigenesis.
XB130 (AFAP1L2) is an adaptor protein involved in many cellular functions, such as cell survival, cell proliferation, migration, and gene and miRNA expression.
XB130’s functional domains and motifs enable its interaction with a multitude of proteins involved in several different signaling pathways.
As a tyrosine kinase substrate, tyrosine phosphorylated XB130 associates with the p85α regulatory subunit of phosphoinositol-3-kinase (PI3K) and subsequently affects Akt activity and its downstream signalling.
Tumourigenesis studies show that downregulation of XB130 expression by RNAi inhibits tumor growth in mouse xenograft models.
Furthermore, XB130 affects tumor oncogenicity by regulating the expression of specific tumour suppressing miRNAs.
The expression level and pattern of XB130 has been studied in various human tumors, such as thyroid, esophageal, and gastric cancers, as well as, soft tissue tumors.
Studies show the significant effects of XB130 in tumourigenesis and suggest its potential as a diagnostic biomarker and therapeutic target for cancer treatments.
American Psychological Association (APA)
Bai, Xiao-Hui& Cho, Hae-Ra& Moodley, Serisha& Liu, Mingyao. 2014. XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis. Scientifica،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047603
Modern Language Association (MLA)
Bai, Xiao-Hui…[et al.]. XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis. Scientifica No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047603
American Medical Association (AMA)
Bai, Xiao-Hui& Cho, Hae-Ra& Moodley, Serisha& Liu, Mingyao. XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047603