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Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development
Joint Authors
Garcia, Cynthia
Gutmann, David H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Development is a tightly regulated process that involves stem cell self-renewal, differentiation, cell-to-cell communication, apoptosis, and blood vessel formation.
These coordinated processes ensure that tissues maintain a size and architecture that is appropriate for normal tissue function.
As such, tumors arise when cells acquire genetic mutations that allow them to escape the normal growth constraints.
In this regard, the study of tumor predisposition syndromes affords a unique platform to better understand normal development and the process by which normal cells transform into cancers.
Herein, we review the processes governing normal brain development, discuss how brain cancer represents a disruption of these normal processes, and highlight insights into both normal development and cancer made possible by the study of tumor predisposition syndromes.
American Psychological Association (APA)
Garcia, Cynthia& Gutmann, David H.. 2014. Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development. Scientifica،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047607
Modern Language Association (MLA)
Garcia, Cynthia& Gutmann, David H.. Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development. Scientifica No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047607
American Medical Association (AMA)
Garcia, Cynthia& Gutmann, David H.. Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047607