Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options
Joint Authors
Goudarzi, Mehdi
Seyedjavadi, Sima Sadat
Goudarzi, Hossein
Mehdizadeh Aghdam, Elnaz
Nazeri, Saeed
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence and mortality rate of Clostridium difficile infection have increased remarkably in both hospital and community settings during the last two decades.
The growth of infection may be caused by multiple factors including inappropriate antibiotic usage, poor standards of environmental cleanliness, changes in infection control practices, large outbreaks of C.
difficile infection in hospitals, alteration of circulating strains of C.
difficile, and spread of hypervirulent strains.
Detection of high-risk populations could be helpful for prompt diagnosis and consequent treatment of patients suffering from C.
difficile infection.
Metronidazole and oral vancomycin are recommended antibiotics for the treatment of initial infection.
Current treatments for C.
difficile infection consist of supportive care, discontinuing the unnecessary antibiotic, and specific antimicrobial therapy.
Moreover, novel approaches include fidaxomicin therapy, monoclonal antibodies, and fecal microbiota transplantation mediated therapy.
Fecal microbiota transplantation has shown relevant efficacy to overcome C.
difficile infection and reduce its recurrence.
American Psychological Association (APA)
Goudarzi, Mehdi& Seyedjavadi, Sima Sadat& Goudarzi, Hossein& Mehdizadeh Aghdam, Elnaz& Nazeri, Saeed. 2014. Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options. Scientifica،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047609
Modern Language Association (MLA)
Goudarzi, Mehdi…[et al.]. Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options. Scientifica No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047609
American Medical Association (AMA)
Goudarzi, Mehdi& Seyedjavadi, Sima Sadat& Goudarzi, Hossein& Mehdizadeh Aghdam, Elnaz& Nazeri, Saeed. Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options. Scientifica. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047609