Relationships between Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure Treatment, and Inflammatory Cytokines
Joint Authors
Ünüvar Doğan, Filiz
Kuzu Okur, Hacer
Can, Ümmügülsüm
Yosunkaya, Şebnem
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The cardiovascular complications that frequently accompany obstructive sleep apnea syndrome (OSAS) are thought to develop as a result of inflammatory stress associated with cytokines such as IL-6 and TNF-α.
We conducted the current study to compare levels of these cytokines in OSAS patients ( n = 33 ) and nonapneic controls ( n = 24 ) .
Furthermore, we investigated the impact of a three-month regime of continuous positive airway pressure (CPAP) on serum levels of IL-6 and TNF-α only in the OSAS patients.
There were no significant differences in serum levels of either IL-6 ( P = 0.782 ) or TNF- α ( P = 0.722 ) or TNF-α ( P = 0.722 ) between OSAS patients and nonapneic controls.
Serum IL-6 levels correlated significantly with neck circumference in OSAS patients ( P = 0.006 ).
In OSAS patients, reduced levels of TNF-α and IL-6 correlated with increases in mean SaO2 after CPAP treatment ( P = 0.020 and P = 0.051 , resp.).
However, neither of cytokine levels was significantly impacted by CPAP therapy (both P > 0.137 ).
We have demonstrated that plasma cytokine levels are similar in both otherwise healthy subjects with OSAS and in nonapneic control, and we conclude that OSAS-related parameters and CPAP treatment do not play a significant role in altering cytokine levels.
American Psychological Association (APA)
Ünüvar Doğan, Filiz& Yosunkaya, Şebnem& Kuzu Okur, Hacer& Can, Ümmügülsüm. 2014. Relationships between Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure Treatment, and Inflammatory Cytokines. Sleep Disorders،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047624
Modern Language Association (MLA)
Ünüvar Doğan, Filiz…[et al.]. Relationships between Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure Treatment, and Inflammatory Cytokines. Sleep Disorders No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047624
American Medical Association (AMA)
Ünüvar Doğan, Filiz& Yosunkaya, Şebnem& Kuzu Okur, Hacer& Can, Ümmügülsüm. Relationships between Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure Treatment, and Inflammatory Cytokines. Sleep Disorders. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047624