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Narcolepsy as an Immune-Mediated Disease
Joint Authors
De la Herrán-Arita, Alberto K.
García-García, Fabio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagonic hallucinations, sleep paralysis, and disturbed nocturnal sleep patterns.
This disease is secondary to the specific loss of hypothalamic hypocretin (orexin)-producing neurons in the lateral hypothalamus.
An autoimmune basis for the disease has long been suspected based on its strong association with the genetic marker DQB1*06:02, and current studies greatly support this hypothesis.
Narcolepsy with hypocretin deficiency is associated with human leukocyte antigen (HLA) and T cell receptor (TCR) polymorphisms, suggesting that an autoimmune process targets a peptide unique to hypocretin-producing neurons via specific HLA-peptide-TCR interactions.
This concept has gained a lot of notoriety after the increase of childhood narcolepsy in 2010 following the 2009 H1N1 pandemic (pH1N1) in China and vaccination with Pandemrix, an adjuvanted H1N1 vaccine that was used in Scandinavia.
The surge of narcolepsy cases subsequent to influenza A H1N1 infection and H1N1 vaccination suggests that processes such as molecular mimicry or bystander activation might be crucial for disease development.
American Psychological Association (APA)
De la Herrán-Arita, Alberto K.& García-García, Fabio. 2014. Narcolepsy as an Immune-Mediated Disease. Sleep Disorders،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047629
Modern Language Association (MLA)
De la Herrán-Arita, Alberto K.& García-García, Fabio. Narcolepsy as an Immune-Mediated Disease. Sleep Disorders No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047629
American Medical Association (AMA)
De la Herrán-Arita, Alberto K.& García-García, Fabio. Narcolepsy as an Immune-Mediated Disease. Sleep Disorders. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047629