![](/images/graphics-bg.png)
Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants
Joint Authors
Chuke, Stella O.
Yen, Nguyen Thi Ngoc
Laserson, Kayla F.
Phuoc, Nguyen Huu
Trinh, Nguyen An
Nhung, Duong Thi Cam
Mai, Vo Thi Chi
Qui, An Dang
Hai, Hoang Hoa
Loan, Le Thien Huong
Jones, Warren G.
Whitworth, William C.
Shah, J. Jina
Painter, John A.
Mazurek, Gerald H.
Maloney, Susan A.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Use of tuberculin skin tests (TSTs) and interferon gamma release assays (IGRAs) as part of tuberculosis (TB) screening among immigrants from high TB-burden countries has not been fully evaluated.
Methods.
Prevalence of Mycobacterium tuberculosis infection (MTBI) based on TST, or the QuantiFERON-TB Gold test (QFT-G), was determined among immigrant applicants in Vietnam bound for the United States (US); factors associated with test results and discordance were assessed; predictive values of TST and QFT-G for identifying chest radiographs (CXRs) consistent with TB were calculated.
Results.
Of 1,246 immigrant visa applicants studied, 57.9% were TST positive, 28.3% were QFT-G positive, and test agreement was 59.4%.
Increasing age was associated with positive TST results, positive QFT-G results, TST-positive but QFT-G-negative discordance, and abnormal CXRs consistent with TB.
Positive predictive values of TST and QFT-G for an abnormal CXR were 25.9% and 25.6%, respectively.
Conclusion.
The estimated prevalence of MTBI among US-bound visa applicants in Vietnam based on TST was twice that based on QFT-G, and 14 times higher than a TST-based estimate of MTBI prevalence reported for the general US population in 2000.
QFT-G was not better than TST at predicting abnormal CXRs consistent with TB.
American Psychological Association (APA)
Chuke, Stella O.& Yen, Nguyen Thi Ngoc& Laserson, Kayla F.& Phuoc, Nguyen Huu& Trinh, Nguyen An& Nhung, Duong Thi Cam…[et al.]. 2014. Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants. Tuberculosis Research and Treatment،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1048059
Modern Language Association (MLA)
Chuke, Stella O.…[et al.]. Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants. Tuberculosis Research and Treatment No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1048059
American Medical Association (AMA)
Chuke, Stella O.& Yen, Nguyen Thi Ngoc& Laserson, Kayla F.& Phuoc, Nguyen Huu& Trinh, Nguyen An& Nhung, Duong Thi Cam…[et al.]. Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants. Tuberculosis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1048059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048059