Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages
Joint Authors
Source
Tuberculosis Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Tuberculosis is a serious problem of public health.
The increase on the number of clinical cases of tuberculosis infected with multidrug resistant (MDR) M.
tuberculosis calls for the development of novel therapy.
Design.
We investigated the effect of mefloquine and two enantiomers, (+)erythro-mefloquine and (+)threo-mefloquine against M.
tuberculosis strains in the environment resembling the aspects of the granuloma environment and in macrophages.
Results.
The results suggest that mefloquine (racemic mixture) and (+)erythro-mefloquine have bactericidal activity against M.
tuberculosis strains both in acidic, low oxygen tension and in macrophages.
The activity, however, was impaired under increased osmolarity.
Conclusion.
Identification of the target for mefloquine in the pathogen will allow for the development of novel drugs with antituberculosis activity.
American Psychological Association (APA)
Bermudez, Luiz E.& Meek, Laura. 2014. Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages. Tuberculosis Research and Treatment،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1048066
Modern Language Association (MLA)
Bermudez, Luiz E.& Meek, Laura. Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages. Tuberculosis Research and Treatment No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1048066
American Medical Association (AMA)
Bermudez, Luiz E.& Meek, Laura. Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages. Tuberculosis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1048066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048066