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In Silico Antitubercular Activity Analysis of Benzofuran and Naphthofuran Derivatives
Joint Authors
Karunakar, Prashantha
Girija, Chamarahalli Ramakrishnaiyer
Krishnamurthy, Venkatappa
Krishna, Venkatarangaiah
Shivakumar, Kunigal Venugopal
Source
Tuberculosis Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
For the human health, Mycobacterium tuberculosis (MTB) is the deadliest enemy since decades due to its multidrug resistant strains.
During latent stage of tuberculosis infection, MTB consumes nitrate as the alternate mechanism of respiration in the absence of oxygen, thus increasing its survival and virulence.
NarL is a nitrate/nitrite response transcriptional regulatory protein of two-component signal transduction system which regulates nitrate reductase and formate dehydrogenase for MTB adaptation to anaerobic condition.
Phosphorylation by sensor kinase (NarX) is the primary mechanism behind the activation of NarL although many response regulators get activated by small molecule phospho-donors in the absence of sensor kinase.
Using in silico approach, the molecular docking of benzofuran and naphthofuran derivatives and dynamic study of benzofuran derivative were performed.
It was observed that compound Ethyl 5-bromo-3-ethoxycarbonylamino-1-benzofuran-2-carboxylate could be stabilized at the active site for over 10 ns of simulation.
Here we suggest that derivatives of benzofuran moiety can lead to developing novel antituberculosis drugs.
American Psychological Association (APA)
Karunakar, Prashantha& Girija, Chamarahalli Ramakrishnaiyer& Krishnamurthy, Venkatappa& Krishna, Venkatarangaiah& Shivakumar, Kunigal Venugopal. 2014. In Silico Antitubercular Activity Analysis of Benzofuran and Naphthofuran Derivatives. Tuberculosis Research and Treatment،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048071
Modern Language Association (MLA)
Karunakar, Prashantha…[et al.]. In Silico Antitubercular Activity Analysis of Benzofuran and Naphthofuran Derivatives. Tuberculosis Research and Treatment No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1048071
American Medical Association (AMA)
Karunakar, Prashantha& Girija, Chamarahalli Ramakrishnaiyer& Krishnamurthy, Venkatappa& Krishna, Venkatarangaiah& Shivakumar, Kunigal Venugopal. In Silico Antitubercular Activity Analysis of Benzofuran and Naphthofuran Derivatives. Tuberculosis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048071