Preparation of Tween 80-ZnAl-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System

Abstract EN

We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite.

Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite.

The final product is called Tween-dopa-LDH nanocomposite.

The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure.

From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively.

The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied.

The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect.

The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay).