Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer
Joint Authors
Al-Suwayeh, S. A.
Taha, Ehab I.
Al-Qahtani, Fahad M.
Ahmed, Mahrous O.
Badran, Mohamed
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The current study was designed to develop a topical gel formulation for improved skin penetration of lornoxicam (LOR) for enhancement of its analgesic activity.
Moreover, the effect of different penetration enhancers on LOR was studied.
The LOR gel formulations were prepared by using hydroxylpropyl methylcellulose (HPMC) and carbopol.
The carbopol gels in presence of propylene glycol (PG) and ethanol were developed.
The formulated gels were characterized for pH, viscosity, and LOR release using Franz diffusion cells.
Also, in vitro skin permeation of LOR was conducted.
The effect of hydroxypropyl β-cyclodextrin (HP β-CD), beta-cyclodextrin (β-CD), Tween 80, and oleic acid on LOR permeation was evaluated.
The optimized LOR gel formulation (LORF8) showed the highest flux (14.31 μg/cm2/h) with ER of 18.34 when compared to LORF3.
Incorporation of PG and HP β-CD in gel formulation (LORF8) enhanced the permeation of LOR significantly.
It was observed that LORF3 and LORF8 show similar analgesic activity compared to marketed LOR injection (Xefo).
This work shows that LOR can be formulated into carbopol gel in presence of PG and HP β-CD and may be promising in enhancing permeation.
American Psychological Association (APA)
Al-Suwayeh, S. A.& Taha, Ehab I.& Al-Qahtani, Fahad M.& Ahmed, Mahrous O.& Badran, Mohamed. 2014. Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1048384
Modern Language Association (MLA)
Al-Suwayeh, S. A.…[et al.]. Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1048384
American Medical Association (AMA)
Al-Suwayeh, S. A.& Taha, Ehab I.& Al-Qahtani, Fahad M.& Ahmed, Mahrous O.& Badran, Mohamed. Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1048384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048384