Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
Joint Authors
Li, Tsai-Chung
Hsu, Hsin-Cheng
Lin, Yi-Wen
Liu, Hsu-Jan
Tang, Nou-Ying
Hsieh, Ching-Liang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We adopt the chronic constriction injury (CCI) model to induce neuropathic pain to Spragrue-Dawley (SD) rats by ligating the right sciatic nerve of using four 4-0 chromic gut sutures and subsequently applying 2 and 15 Hz electroacupuncture (EA), respectively, to the right (ipsilateral) Zusanli (St-36) and Shangjuxu (St-37) acupoints.
The results of this study are summarized as follows: (1) the differences in withdrawal latencies for the radiant heat test and total lift leg counts for the cold plate test (4°C) of the control (i.e., non-EA) and sham groups were greater than those of the 2 Hz EA (2EA) and 15 Hz EA (15EA) groups; (2) the von Frey test filament gram counts of the control and sham groups were less than those of the 2EA and 15EA groups on the 6th, 7th, 8th, 11th, 12th, and 13th day following ligation; and (3) the 2EA and 15EA groups exhibited reduced cerebral transient receptor potential vanilloid type 4 (TRPV4) expressions, although we did not observe a similar effect for cerebral TRPV1 or spinal TRPV4/TRPV1 expressions.
These findings show that 2 and 15 Hz EA can reduce CCI-induced neuropathic pain, which indicates that various spinal segmental and gate effects have a crucial function in pain reduction.
The relationship between EA and TRPV4/TRPV1 expression requires further study.
American Psychological Association (APA)
Hsu, Hsin-Cheng& Tang, Nou-Ying& Lin, Yi-Wen& Li, Tsai-Chung& Liu, Hsu-Jan& Hsieh, Ching-Liang. 2014. Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1048394
Modern Language Association (MLA)
Hsu, Hsin-Cheng…[et al.]. Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1048394
American Medical Association (AMA)
Hsu, Hsin-Cheng& Tang, Nou-Ying& Lin, Yi-Wen& Li, Tsai-Chung& Liu, Hsu-Jan& Hsieh, Ching-Liang. Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1048394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048394