Prediction of Early Response to Chemotherapy in Lung Cancer by Using Diffusion-Weighted MR Imaging
Joint Authors
Yu, Jing
Li, Weidong
Zhang, Zhang
Yu, Tielian
Li, Dong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
To determine whether change of apparent diffusion coefficient (ADC) value could predict early response to chemotherapy in lung cancer.
Materials and Methods.
Twenty-five patients with advanced non-small cell lung cancer underwent chest MR imaging including DWI before and at the end of the first cycle of chemotherapy.
The tumor’s mean ADC value and diameters on MR images were calculated and compared.
The grouping reference was based on serial CT scans according to Response Evaluation Criteria in Solid Tumors.
Logistic regression was applied to assess treatment response prediction ability of ADC value and diameters.
Results.
The change of ADC value in partial response group was higher than that in stable disease group ( P = 0.004 ).
ROC curve showed that ADC value could predict treatment response with 100% sensitivity, 64.71% specificity, 57.14% positive predictive value, 100% negative predictive value, and 82.7% accuracy.
The area under the curve for combination of ADC value and longest diameter change was higher than any parameter alone ( P ≤ 0.01 ).
Conclusions.
The change of ADC value may be a sensitive indicator to predict early response to chemotherapy in lung cancer.
Prediction ability could be improved by combining the change of ADC value and longest diameter.
American Psychological Association (APA)
Yu, Jing& Li, Weidong& Zhang, Zhang& Yu, Tielian& Li, Dong. 2014. Prediction of Early Response to Chemotherapy in Lung Cancer by Using Diffusion-Weighted MR Imaging. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048417
Modern Language Association (MLA)
Yu, Jing…[et al.]. Prediction of Early Response to Chemotherapy in Lung Cancer by Using Diffusion-Weighted MR Imaging. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048417
American Medical Association (AMA)
Yu, Jing& Li, Weidong& Zhang, Zhang& Yu, Tielian& Li, Dong. Prediction of Early Response to Chemotherapy in Lung Cancer by Using Diffusion-Weighted MR Imaging. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048417