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Adaptation of Mycoplasmas to Antimicrobial Agents: Acholeplasma laidlawii Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target
Joint Authors
Chernov, Vladislav M.
Medvedeva, Elena S.
Baranova, Natalia B.
Grigorieva, Tatiana Yu.
Davydova, Marina N.
Chernova, Olga A.
Mouzykantov, Alexey A.
Trushin, Maxim V.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes).
This study assessed the differences in susceptibility to ciprofloxacin among strains of Acholeplasma laidlawii PG8.
The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level.
A.
laidlawii extracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin.
These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations.
American Psychological Association (APA)
Medvedeva, Elena S.& Baranova, Natalia B.& Mouzykantov, Alexey A.& Grigorieva, Tatiana Yu.& Davydova, Marina N.& Trushin, Maxim V.…[et al.]. 2014. Adaptation of Mycoplasmas to Antimicrobial Agents: Acholeplasma laidlawii Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048486
Modern Language Association (MLA)
Medvedeva, Elena S.…[et al.]. Adaptation of Mycoplasmas to Antimicrobial Agents: Acholeplasma laidlawii Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048486
American Medical Association (AMA)
Medvedeva, Elena S.& Baranova, Natalia B.& Mouzykantov, Alexey A.& Grigorieva, Tatiana Yu.& Davydova, Marina N.& Trushin, Maxim V.…[et al.]. Adaptation of Mycoplasmas to Antimicrobial Agents: Acholeplasma laidlawii Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048486