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The Effect of Hydroxyl Moieties and Their Oxosubstitution on Bile Acid Association Studied in Floating Monolayers
Joint Authors
Szekeres, Márta
Viskolcz, Béla
Poša, Mihalj
Csanádi, János
Škorić, Dušan
Illés, Erzsébet
Tóth, Ildikó Y.
Tombácz, Etelka
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Bile salt aggregates are promising candidates for drug delivery vehicles due to their unique fat-solubilizing ability.
However, the toxicity of bile salts increases with improving fat-solubilizing capability and so an optimal combination of efficient solubilization and low toxicity is necessary.
To improve hydrophilicity (and decrease toxicity), we substituted hydroxyl groups of several natural bile acid (BA) molecules for oxogroups and studied their intrinsic molecular association behavior.
Here we present the comparative Langmuir trough study of the two-dimensional (2D) association behavior of eight natural BAs and four oxoderivatives (traditionally called keto-derivatives) floated on an aqueous subphase.
The series of BAs and derivatives showed systematic changes in the shape of the compression isotherms.
Two types of association could be distinguished: the first transition was assigned to the formation of dimers through H-bonding and the second to the hydrophobic aggregation of BA dimers.
Hydrophobic association of BA molecules in the films is linked to the ability of forming H-bonded dimers.
Both H-bond formation and hydrophobic association weakened with increasing number of hydroxyl groups, decreasing distance between hydroxyl groups, and increasing oxosubstitution.
The results also show that the Langmuir trough method is extremely useful in selecting appropriate BA molecules to design drug delivery systems.
American Psychological Association (APA)
Szekeres, Márta& Viskolcz, Béla& Poša, Mihalj& Csanádi, János& Škorić, Dušan& Illés, Erzsébet…[et al.]. 2014. The Effect of Hydroxyl Moieties and Their Oxosubstitution on Bile Acid Association Studied in Floating Monolayers. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048494
Modern Language Association (MLA)
Szekeres, Márta…[et al.]. The Effect of Hydroxyl Moieties and Their Oxosubstitution on Bile Acid Association Studied in Floating Monolayers. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1048494
American Medical Association (AMA)
Szekeres, Márta& Viskolcz, Béla& Poša, Mihalj& Csanádi, János& Škorić, Dušan& Illés, Erzsébet…[et al.]. The Effect of Hydroxyl Moieties and Their Oxosubstitution on Bile Acid Association Studied in Floating Monolayers. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048494