Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Because tumor cells grow rapidly and randomly, hypoxic regions arise from the lack of oxygen supply in solid tumors.
Hypoxic regions in tumors are known to be resistant to chemotherapy and radiotherapy.
Hypoxia-inducible factor-1 (HIF-1) expressed in hypoxic regions regulates the expression of genes related to tumor growth, angiogenesis, metastasis, and therapy resistance.
Thus, imaging of HIF-1-active regions in tumors is of great interest.
HIF-1 activity is regulated by the expression and degradation of its α subunit (HIF-1α), which is degraded in the proteasome under normoxic conditions, but escapes degradation under hypoxic conditions, allowing it to activate transcription of HIF-1-target genes.
Therefore, to image HIF-1-active regions, HIF-1-dependent reporter systems and injectable probes that are degraded in a manner similar to HIF-1α have been recently developed and used in preclinical studies.
However, no probe currently used in clinical practice directly assesses HIF-1 activity.
Whether the accumulation of 18F-FDG or 18F-FMISO can be utilized as an index of HIF-1 activity has been investigated in clinical studies.
In this review, the current status of HIF-1 imaging in preclinical and clinical studies is discussed.
American Psychological Association (APA)
Ueda, Masashi& Saji, Hideo. 2014. Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048554
Modern Language Association (MLA)
Ueda, Masashi& Saji, Hideo. Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1048554
American Medical Association (AMA)
Ueda, Masashi& Saji, Hideo. Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048554