IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients
Joint Authors
Jost, Sheridan A.
Tseng, Lin-Chiang
Matthews, Loderick A.
Vasquez, Rebecca
Zhang, Song
Yancey, Kim B.
Chong, Benjamin F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
IgG antinuclear antibodies (ANAs) are elevated in patients with systemic lupus erythematosus (SLE) compared with patients with discoid lupus erythematosus (DLE).
To provide an expanded immunologic view of circulating ANAs in lupus patients, we compared the expressions of IgG, IgM, and IgA ANAs in DLE and SLE patients.
In this cross-sectional study, sera from age-, gender-, and ethnic-matched SLE N=35, DLE N=23, and normal patients N=22 were tested for IgG, IgM, and IgA ANAs using enzyme-linked immunosorbent assays (ELISAs) and indirect immunofluorescence (IIF) with monkey esophagus as substrate.
ELISAs showed elevated levels of IgG ANA, IgM ANA, and IgG/IgM ANA ratios in SLE patients compared with DLE and normal patients.
IgA ANA expression was higher in SLE and DLE patients versus normal patients.
IIF studies showed higher percentages of patients positive for IgG, IgM, and IgA ANAs in the SLE group.
Higher IgG/IgM ANA ratios in SLE than DLE show enhanced class-switching and a more sustained humoral response in SLE.
They also suggest a potential connection of IgM ANAs with disease containment.
American Psychological Association (APA)
Jost, Sheridan A.& Tseng, Lin-Chiang& Matthews, Loderick A.& Vasquez, Rebecca& Zhang, Song& Yancey, Kim B.…[et al.]. 2014. IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048576
Modern Language Association (MLA)
Jost, Sheridan A.…[et al.]. IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048576
American Medical Association (AMA)
Jost, Sheridan A.& Tseng, Lin-Chiang& Matthews, Loderick A.& Vasquez, Rebecca& Zhang, Song& Yancey, Kim B.…[et al.]. IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048576