Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats
Joint Authors
Kaithwas, Gaurav
Shukla, Kamleshwar
Raj, Prince
Kumar, Arun
Kumar, Mukesh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The present study was undertaken to elucidate the effect of pantoprazole and aprepitant on experimental esophagitis in albino rats.
Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation.
Animals were sacrificed after 8 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index, and free acidity.
Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD.
Treatment with pantoprazole and aprepitant significantly inhibited the gastric secretion, total acidity, and esophagitis index.
The treatment also helped to restore the altered levels oxidative stress parameters to normal.
American Psychological Association (APA)
Shukla, Kamleshwar& Raj, Prince& Kumar, Arun& Kumar, Mukesh& Kaithwas, Gaurav. 2014. Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048632
Modern Language Association (MLA)
Shukla, Kamleshwar…[et al.]. Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048632
American Medical Association (AMA)
Shukla, Kamleshwar& Raj, Prince& Kumar, Arun& Kumar, Mukesh& Kaithwas, Gaurav. Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048632