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PET and PETCT with 68Gallium-Labeled Somatostatin Analogues in Non GEP-NETs Tumors
Joint Authors
Sollini, M.
Erba, P. A.
Fraternali, Alessandro
Di Paolo, Maria Liberata
Froio, Armando
Frasoldati, Andrea
Versari, A.
Casali, M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine cells.
A major interest for SST receptors (SSTR) as target for in vivo diagnostic and therapeutic purposes was born since a series of stable synthetic SST-analouges PET became available, being the native somatostatin non feasible for clinical use due to the very low metabolic stability.
The rationale for the employment of SST-analogues to image cancer is both based on the expression of SSTR by tumor and on the high affinity of these compounds for SSTR.
The primary indication of SST-analogues imaging is for neuroendocrine tumors (NETs), which usually express a high density of SSTR, so they can be effectively targeted and visualized with radiolabeled SST-analogues in vivo.
Particularly, SST-analogues imaging has been widely employed in gastroenteropancreatic (GEP) NETs.
Nevertheless, a variety of tumors other than NETs expresses SSTR thus SST-analogues imaging can also be used in these tumors, particularly if treatment with radiolabeled therapeutic SST-analouges PET is being considered.
The aim of this paper is to provide a concise overview of the role of positron emission tomography/computed tomography (PET/CT) with 68Ga-radiolabeled SST-analouges PET in tumors other than GEP-NETs.
American Psychological Association (APA)
Sollini, M.& Erba, P. A.& Fraternali, Alessandro& Casali, M.& Di Paolo, Maria Liberata& Froio, Armando…[et al.]. 2014. PET and PETCT with 68Gallium-Labeled Somatostatin Analogues in Non GEP-NETs Tumors. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1048679
Modern Language Association (MLA)
Sollini, M.…[et al.]. PET and PETCT with 68Gallium-Labeled Somatostatin Analogues in Non GEP-NETs Tumors. The Scientific World Journal No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-1048679
American Medical Association (AMA)
Sollini, M.& Erba, P. A.& Fraternali, Alessandro& Casali, M.& Di Paolo, Maria Liberata& Froio, Armando…[et al.]. PET and PETCT with 68Gallium-Labeled Somatostatin Analogues in Non GEP-NETs Tumors. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1048679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048679