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Diagnostic Performance of Positron Emission TomographyComputed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Treglia, Giorgio
Sadeghi, Ramin
Ayati, Narjes
Giovanella, Luca
Annunziata, Salvatore
Caldarella, Carmelo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
The diagnostic performance of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results.
The aim of our study is to systematically review and meta-analyze published data about this topic.
Methods.
A comprehensive computer literature search of PubMed/MEDLINE, Scopus, and Embase databases was carried out on July 10 to find relevant articles concerning the diagnostic performance of FDG-PET in detecting locoregional nodal involvement in patients with ACC.
No language restriction was used.
Pooled diagnostic performance on a lesion-based analysis was calculated.
Results.
Seven retrospective and five prospective studies have been reviewed.
Six studies allowed assessing pooled sensitivity; five studies allowed assessing pooled specificity.
Sensitivity and specificity values of FDG-PET/CT on a lesion-based analysis ranged from 31 to 100% and from 53 to 98%, with pooled estimates of 56% (95% CI: 45–67%) and 90% (95% CI: 86–93%), respectively.
Conclusions.
Our meta-analysis demonstrates that FDG-PET is a specific diagnostic tool in detecting locoregional lymph node involvement in patients with ACC.
Low sensitivity is a major concern; however, higher sensitivity could be reached combining FDG-PET with MR scan.
American Psychological Association (APA)
Caldarella, Carmelo& Annunziata, Salvatore& Treglia, Giorgio& Sadeghi, Ramin& Ayati, Narjes& Giovanella, Luca. 2014. Diagnostic Performance of Positron Emission TomographyComputed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1048694
Modern Language Association (MLA)
Caldarella, Carmelo…[et al.]. Diagnostic Performance of Positron Emission TomographyComputed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1048694
American Medical Association (AMA)
Caldarella, Carmelo& Annunziata, Salvatore& Treglia, Giorgio& Sadeghi, Ramin& Ayati, Narjes& Giovanella, Luca. Diagnostic Performance of Positron Emission TomographyComputed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1048694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048694