The Limbic Degradation of Aging Brain: A Quantitative Analysis with Diffusion Tensor Imaging
Joint Authors
Gunbey, Hediye Pınar
Ercan, Karabekir
Fındıkoglu, Ayşe Serap
Bulut, H. Taner
Karaoglanoglu, Mustafa
Arslan, Halil
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Introduction.
The limbic system primarily responsible for our emotional life and memories is known to undergo degradation with aging and diffusion tensor imaging (DTI) is capable of revealing the white matter integrity.
The aim of this study is to investigate age-related changes of quantitative diffusivity parameters and fiber characteristics on limbic system in healthy volunteers.
Methods.
31 healthy subjects aged 25–70 years were examined at 1,5 TMR.
Quantitative fiber tracking was performed of fornix, cingulum, and the parahippocampal gyrus.
The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements of bilateral hippocampus, amygdala, fornix, cingulum, and parahippocampal gyrus were obtained as related components.
Results.
The FA values of left hippocampus, bilateral parahippocampal gyrus, and fornix showed negative correlations with aging.
The ADC values of right amygdala and left cingulum interestingly showed negative relation and the left hippocampus represented positive relation with age.
The cingulum showed no correlation.
The significant relative changes per decade of age were found in the cingulum and parahippocampal gyrus FA measurements.
Conclusion.
Our approach shows that aging affects hippocampus, parahippocampus, and fornix significantly but not cingulum.
These findings reveal age-related changes of limbic system in normal population that may contribute to future DTI studies.
American Psychological Association (APA)
Gunbey, Hediye Pınar& Ercan, Karabekir& Fındıkoglu, Ayşe Serap& Bulut, H. Taner& Karaoglanoglu, Mustafa& Arslan, Halil. 2014. The Limbic Degradation of Aging Brain: A Quantitative Analysis with Diffusion Tensor Imaging. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048697
Modern Language Association (MLA)
Gunbey, Hediye Pınar…[et al.]. The Limbic Degradation of Aging Brain: A Quantitative Analysis with Diffusion Tensor Imaging. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048697
American Medical Association (AMA)
Gunbey, Hediye Pınar& Ercan, Karabekir& Fındıkoglu, Ayşe Serap& Bulut, H. Taner& Karaoglanoglu, Mustafa& Arslan, Halil. The Limbic Degradation of Aging Brain: A Quantitative Analysis with Diffusion Tensor Imaging. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048697