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Association of Leukocytosis with Amphetamine and Cocaine Use
Joint Authors
Farias, Valeria F.
Clingan, Chris S.
Richards, John R.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
Determining the etiology of unexplained leukocytosis in asymptomatic patients may incur unnecessary testing, cost, and prolonged emergency department stay.
The objective was to delineate if use of amphetamines and/or cocaine is a factor.
Methods.
For two years we reviewed all psychiatric patients presenting for medical clearance with exclusions for infection, epilepsy, trauma, or other nonpsychiatric medical conditions.
Results.
With a total of 1,206 patients, 877 (72.7%) amphetamines/cocaine-negative drug screen controls had mean WBC 8.4±2.6×103/µL.
The 240 (19.9%) amphetamines-positive, cocaine-negative, patients had WBC 9.4±3.3×103/µL (P<0.0001).
The 72 (6.0%) amphetamines-negative, cocaine-positive, patients had WBC 7.1±1.8×103/µL (P<0.0001).
The remaining 17 (1.4%) amphetamines/cocaine-positive patients had WBC 10.0±4.2×103/µL (P=0.01).
Amphetamines-positive patients had a supranormal WBC ratio significantly higher than controls (23.8% versus 14.8%, P=0.001), whereas only one cocaine-positive patient had a supranormal WBC count, with significantly lower ratio (1.4%, P=0.0003).
Conclusion.
Use of amphetamines, not cocaine, may be associated with idiopathic leukocytosis.
This may be explained by unique pharmacologic, neuroendocrine, and immunomodulatory differences.
American Psychological Association (APA)
Richards, John R.& Farias, Valeria F.& Clingan, Chris S.. 2014. Association of Leukocytosis with Amphetamine and Cocaine Use. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048731
Modern Language Association (MLA)
Richards, John R.…[et al.]. Association of Leukocytosis with Amphetamine and Cocaine Use. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048731
American Medical Association (AMA)
Richards, John R.& Farias, Valeria F.& Clingan, Chris S.. Association of Leukocytosis with Amphetamine and Cocaine Use. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048731