![](/images/graphics-bg.png)
Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells
Joint Authors
Abdulla, Mahmood Ameen
Paydar, Mohammadjavad
Looi, Chung Yeng
Abdul Majid, Nazia
Gwaram, Nura Suleiman
Ahmad, N.
Faraj, Fadhil Lafta
Zahedifard, Maryam
Ali, Hapipah Mohd
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Two new synthesized and characterized quinazoline Schiff bases 1 and 2 were investigated for anticancer activity against MCF-7 human breast cancer cell line.
Compounds 1 and 2 demonstrated a remarkable antiproliferative effect, with an IC50 value of 6.246 × 10−6 mol/L and 5.910 × 10−6 mol/L, respectively, after 72 hours of treatment.
Most apoptosis morphological features in treated MCF-7 cells were observed by AO/PI staining.
The results of cell cycle analysis indicate that compounds did not induce S and M phase arrest in cell after 24 hours of treatment.
Furthermore, MCF-7 cells treated with 1 and 2 subjected to apoptosis death, as exhibited by perturbation of mitochondrial membrane potential and cytochrome c release as well as increase in ROS formation.
We also found activation of caspases-3/7, -8, and -9 in compounds 1 and 2.
Moreover, inhibition of NF-κB translocation in MCF-7 cells treated by compound 1 significantly exhibited the association of extrinsic apoptosis pathway.
Acute toxicity results demonstrated the nontoxic nature of the compounds in mice.
Our results showed significant activity towards MCF-7 cells via either intrinsic or extrinsic mitochondrial pathway and are potential candidate for further in vivo and clinical breast cancer studies.
American Psychological Association (APA)
Faraj, Fadhil Lafta& Zahedifard, Maryam& Paydar, Mohammadjavad& Looi, Chung Yeng& Abdul Majid, Nazia& Ali, Hapipah Mohd…[et al.]. 2014. Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1048747
Modern Language Association (MLA)
Faraj, Fadhil Lafta…[et al.]. Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells. The Scientific World Journal No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1048747
American Medical Association (AMA)
Faraj, Fadhil Lafta& Zahedifard, Maryam& Paydar, Mohammadjavad& Looi, Chung Yeng& Abdul Majid, Nazia& Ali, Hapipah Mohd…[et al.]. Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1048747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048747