Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
Joint Authors
Zhang, Shuangqing
Zhang, Yan
Peng, Ning
Zhang, Haibo
Yao, Juan
Li, Zhihong
Liu, Liegang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available.
The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats.
ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry.
Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively.
Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues.
Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.
American Psychological Association (APA)
Zhang, Shuangqing& Zhang, Yan& Peng, Ning& Zhang, Haibo& Yao, Juan& Li, Zhihong…[et al.]. 2014. Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1048785
Modern Language Association (MLA)
Zhang, Shuangqing…[et al.]. Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats. The Scientific World Journal No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1048785
American Medical Association (AMA)
Zhang, Shuangqing& Zhang, Yan& Peng, Ning& Zhang, Haibo& Yao, Juan& Li, Zhihong…[et al.]. Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1048785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048785