A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats
Joint Authors
Lin, Chia-Hsien
Lin, Pu-Hua
Hsu, Shih-Chung
Chang, Jung-Chen
Wu, Ya-Chieh
Pei, Jin-Kuo
Chang, Wei-Pin
Chang, Wei Chiao
Chien, Shu-Chen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders.
Only a few of the hepatoprotective effects of JWXYS have been studied.
The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN-) induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects.
After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were significantly elevated, whereas the albumin level decreased.
Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated.
In addition, JWXYS treatment prevented liver fibrosis induced by DMN.
JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats.
Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury.
The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.
American Psychological Association (APA)
Chien, Shu-Chen& Chang, Wei Chiao& Lin, Pu-Hua& Chang, Wei-Pin& Hsu, Shih-Chung& Chang, Jung-Chen…[et al.]. 2014. A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048786
Modern Language Association (MLA)
Chien, Shu-Chen…[et al.]. A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1048786
American Medical Association (AMA)
Chien, Shu-Chen& Chang, Wei Chiao& Lin, Pu-Hua& Chang, Wei-Pin& Hsu, Shih-Chung& Chang, Jung-Chen…[et al.]. A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1048786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048786