Physicochemical Characterization and Thermodynamic Studies of Nanoemulsion-Based Transdermal Delivery System for Fullerene
Joint Authors
Basri, Mahiran
Abedi Karjiban, Roghayeh
Ngan, Cheng Loong
Tripathy, Minaketan
Abdul-Malek, Emilia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Fullerene nanoemulsions were formulated in palm kernel oil esters stabilized by low amount of mixed nonionic surfactants.
Pseudoternary phase diagrams were established in the colloidal system of PKOEs/Tween 80 : Span 80/water incorporated with fullerene as antioxidant.
Preformulation was subjected to combination of high and low energy emulsification methods and the physicochemical characteristics of fullerene nanoemulsions were analyzed using electroacoustic spectrometer.
Oil-in-water (O/W) nanoemulsions with particle sizes in the range of 70–160 nm were formed.
The rheological characteristics of colloidal systems exhibited shear thinning behavior which fitted well into the power law model.
The effect of xanthan gum (0.2–1.0%, w/w) and beeswax (1–3%, w/w) in the estimation of thermodynamics was further studied.
From the energetic parameters calculated for the viscous flow, a moderate energy barrier for transport process was observed.
Thermodynamic study showed that the enthalpy was positive in all xanthan gum and beeswax concentrations indicating that the formation of nanoemulsions could be endothermic in nature.
Fullerene nanoemulsions with 0.6% or higher xanthan gum content were found to be stable against creaming and flocculation when exposed to extreme environmental conditions.
American Psychological Association (APA)
Ngan, Cheng Loong& Basri, Mahiran& Tripathy, Minaketan& Abedi Karjiban, Roghayeh& Abdul-Malek, Emilia. 2014. Physicochemical Characterization and Thermodynamic Studies of Nanoemulsion-Based Transdermal Delivery System for Fullerene. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1048791
Modern Language Association (MLA)
Ngan, Cheng Loong…[et al.]. Physicochemical Characterization and Thermodynamic Studies of Nanoemulsion-Based Transdermal Delivery System for Fullerene. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1048791
American Medical Association (AMA)
Ngan, Cheng Loong& Basri, Mahiran& Tripathy, Minaketan& Abedi Karjiban, Roghayeh& Abdul-Malek, Emilia. Physicochemical Characterization and Thermodynamic Studies of Nanoemulsion-Based Transdermal Delivery System for Fullerene. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1048791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048791