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Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
Joint Authors
Kocevar, Nina
Komel, Radovan
Hudler, Petra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-14
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice.
The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms.
Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies.
However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies.
American Psychological Association (APA)
Hudler, Petra& Kocevar, Nina& Komel, Radovan. 2014. Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1048945
Modern Language Association (MLA)
Hudler, Petra…[et al.]. Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics. The Scientific World Journal No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1048945
American Medical Association (AMA)
Hudler, Petra& Kocevar, Nina& Komel, Radovan. Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1048945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048945