Antiproliferative Evaluation of Isofuranodiene on Breast and Prostate Cancer Cell Lines
Joint Authors
Buccioni, Michela
Dal Ben, Diego
Lambertucci, Catia
Maggi, Filippo
Papa, Fabrizio
Thomas, Ajiroghene
Volpini, Rosaria
Marucci, Gabriella
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The anticancer activity of isofuranodiene, extracted from Smyrnium olusatrum, was evaluated in human breast adenocarcinomas MDA-MB 231 and BT 474, and Caucasian prostate adenocarcinoma PC 3 cell lines by MTS assay.
MTS assay showed a dose-dependent growth inhibition in the tumor cell lines after isofuranodiene treatment.
The best antiproliferative activity of the isofuranodiene was found on PC 3 cells with an IC50 value of 29 μ M, which was slightly less than the inhibition against the two breast adenocarcinoma cell lines with IC50 values of 59 and 55 μ M on MDA-MB 231 and BT 474, respectively.
Hoechst 33258 assay was performed in order to study the growth inhibition mechanism in prostate cancer cell line; the results indicate that isofuranodiene induces apoptosis.
Overall, the understudy compound has a good anticancer activity especially towards the PC 3.
On the contrary, it is less active on Chinese hamster ovary cells (CHO) and human embryonic kidney (HEK 293) appearing as a good candidate as a potential natural anticancer drug with low side effects.
American Psychological Association (APA)
Buccioni, Michela& Dal Ben, Diego& Lambertucci, Catia& Maggi, Filippo& Papa, Fabrizio& Thomas, Ajiroghene…[et al.]. 2014. Antiproliferative Evaluation of Isofuranodiene on Breast and Prostate Cancer Cell Lines. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1048966
Modern Language Association (MLA)
Buccioni, Michela…[et al.]. Antiproliferative Evaluation of Isofuranodiene on Breast and Prostate Cancer Cell Lines. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1048966
American Medical Association (AMA)
Buccioni, Michela& Dal Ben, Diego& Lambertucci, Catia& Maggi, Filippo& Papa, Fabrizio& Thomas, Ajiroghene…[et al.]. Antiproliferative Evaluation of Isofuranodiene on Breast and Prostate Cancer Cell Lines. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1048966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048966