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PCLPHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride
Joint Authors
Padilha de Paula, Josiane
Barboza, Fernanda Malaquias
Machado, Willian Moreira
Olchanheski Junior, Luiz Renato
Zawadzki, Sônia Faria
Fernandes, Daniel
Farago, Paulo Vitor
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Microparticles of poly(ε-caprolactone) (PCL) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) containing manidipine dihydrochloride (MAN) were successfully prepared by the simple emulsion/solvent evaporation method.
All formulations showed loading efficiency rates greater than 80% and average particle size less than 8 μm.
Formulations had spherical shape with smooth and porous surface for PCL and PHBV, respectively.
According to Fourier-transform infrared spectroscopy, initial components were not chemically modified during microencapsulation.
X-ray diffraction patterns and differential scanning calorimetry demonstrated that this process led to drug amorphization.
In vitro dissolution studies showed that all microparticles prolonged MAN release, mainly which one obtained using PCL that contained 5% of drug loaded (PCL-M5).
Animal studies demonstrated that formulation PCL-M5 was able to keep the variation of mean arterial pressure after phenylephrine administration up to 24 hours.
These data confirmed the sustained antihypertensive effect of the investigated microparticles.
Results provided an experimental basis for using formulation PCL-M5 as a feasible carrier for oral controlled release of MAN intended for treating high blood pressure.
American Psychological Association (APA)
Barboza, Fernanda Malaquias& Machado, Willian Moreira& Olchanheski Junior, Luiz Renato& Padilha de Paula, Josiane& Zawadzki, Sônia Faria& Fernandes, Daniel…[et al.]. 2014. PCLPHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048979
Modern Language Association (MLA)
Barboza, Fernanda Malaquias…[et al.]. PCLPHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1048979
American Medical Association (AMA)
Barboza, Fernanda Malaquias& Machado, Willian Moreira& Olchanheski Junior, Luiz Renato& Padilha de Paula, Josiane& Zawadzki, Sônia Faria& Fernandes, Daniel…[et al.]. PCLPHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048979