Effect of Fluorosis on Liver Cells of VC Deficient and Wild Type Mice
Joint Authors
Zhao, Fusheng
Wei, Wei
Ma, Yonghui
Stuart, John M.
Li, Xiudian
Wang, Lishi
Sun, DianJun
Jiao, Yan
Gu, Weikuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
For decades, mouse and other rodents have been used for the study of oxidative or related studies such as the effect of fluoride.
It is known that rodents normally synthesize their own vitamin C (VC) due to the presence of a key enzyme in ascorbic acid synthesis, l-gulono-lactone-γ-oxidase (Gulo), while humans do not have the capacity of VC synthesis due to the deletion of most parts of the GULO gene.
The spontaneous fracture (sfx) mouse recently emerged as a model for study of VC deficiency.
We investigated the effect of fluoride on liver cells from wild type Balb/c and sfx mice.
We found that activities of SOD, GPx, and CAT were reduced in both wild type and sfx mice; however, the amount of reduction in the sfx cells is more than that in Balb/c cells.
In addition, while both cells increased MDA, the increase in the sfx cells is greater than that in Balb/c cells.
Gene networks of Sod, Gpx, and Cat in the liver of humans and mice are also different.
Our study suggests that reaction to fluoride in vitamin C deficient mice might be different from that of wild type mice.
American Psychological Association (APA)
Wei, Wei& Jiao, Yan& Ma, Yonghui& Stuart, John M.& Li, Xiudian& Zhao, Fusheng…[et al.]. 2014. Effect of Fluorosis on Liver Cells of VC Deficient and Wild Type Mice. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1049087
Modern Language Association (MLA)
Wei, Wei…[et al.]. Effect of Fluorosis on Liver Cells of VC Deficient and Wild Type Mice. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1049087
American Medical Association (AMA)
Wei, Wei& Jiao, Yan& Ma, Yonghui& Stuart, John M.& Li, Xiudian& Zhao, Fusheng…[et al.]. Effect of Fluorosis on Liver Cells of VC Deficient and Wild Type Mice. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1049087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049087