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PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats
Joint Authors
Kamalidehghan, Behnam
Ahmadipour, Fatemeh
Yehye, Wageeh A.
Kadir, Farkaad A.
Abdulla, Mahmood Ameen
Kassim, Normadiah M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The antifibrotic effects of traditional medicinal herb Caesalpinia sappan (CS) extract on liver fibrosis induced by thioacetamide (TAA) and the expression of transforming growth factor β1 (TGF-β1), α-smooth muscle actin (αSMA), and proliferating cell nuclear antigen (PCNA) in rats were studied.
A computer-aided prediction of antioxidant and hepatoprotective activities was primarily performed with the Prediction Activity Spectra of the Substance (PASS) Program.
Liver fibrosis was induced in male Sprague Dawley rats by TAA administration (0.03% w/v) in drinking water for a period of 12 weeks.
Rats were divided into seven groups: control, TAA, Silymarin (SY), and CS 300 mg/kg body weight and 100 mg/kg groups.
The effect of CS on liver fibrogenesis was determined by Masson’s trichrome staining, immunohistochemical analysis, and western blotting.
In vivo determination of hepatic antioxidant activities, cytochrome P450 2E1 (CYP2E1), and matrix metalloproteinases (MPPS) was employed.
CS treatment had significantly increased hepatic antioxidant enzymes activity in the TAA-treated rats.
Liver fibrosis was greatly alleviated in rats when treated with CS extract.
CS treatment was noted to normalize the expression of TGF-β1, αSMA, PCNA, MMPs, and TIMP1 proteins.
PASS-predicted plant activity could efficiently guide in selecting a promising pharmaceutical lead with high accuracy and required antioxidant and hepatoprotective properties.
American Psychological Association (APA)
Kadir, Farkaad A.& Kassim, Normadiah M.& Abdulla, Mahmood Ameen& Kamalidehghan, Behnam& Ahmadipour, Fatemeh& Yehye, Wageeh A.. 2014. PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1049133
Modern Language Association (MLA)
Kadir, Farkaad A.…[et al.]. PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1049133
American Medical Association (AMA)
Kadir, Farkaad A.& Kassim, Normadiah M.& Abdulla, Mahmood Ameen& Kamalidehghan, Behnam& Ahmadipour, Fatemeh& Yehye, Wageeh A.. PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1049133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049133