Antioxidant Properties of Berberis aetnensis C. Presl (Berberidaceae) Roots Extract and Protective Effects on Astroglial Cell Cultures
Joint Authors
Acquaviva, Rosaria
Campisi, Agata
Bonfanti, Roberta
Raciti, Giuseppina
Amodeo, Andrea
Mastrojeni, Silvana
Ragusa, Salvatore
Iauk, Liliana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Berberis aetnensis C.
Presl (Berberidaceae) is a bushy-spiny shrub common on Mount Etna (Sicily).
We demonstrated that the alkaloid extract of roots of B.
aetnensis C.
Presl contains prevalently berberine and berbamine, possesses antimicrobial properties, and was able to counteract the upregulation evoked by glutamate of tissue transglutaminase in primary rat astroglial cell cultures.
Until now, there are no reports regarding antioxidant properties of B.
aetnensis C.
Presl collected in Sicily.
Air-dried, powdered roots of B.
aetnensis C.
Presl were extracted, identified, and quantified by HPLC.
We assessed in cellular free system its effect on superoxide anion, radicals scavenging activity of antioxidants against free radicals like the 1,1-diphenyl-2-picrylhydrazyl radical, and the inhibition of xanthine oxidase activity.
In primary rat astroglial cell cultures, exposed to glutamate, we evaluated the effect of the extract on glutathione levels and on intracellular production of reactive oxygen species generated by glutamate.
The alkaloid extract of B.
aetnensis C.
Presl inhibited superoxide anion, restored to control values, the decrease of GSH levels, and the production of reactive oxygen species.
Potent antioxidant activities of the alkaloid extract of roots of B.
aetnensis C.
Presl may be one of the mechanisms by which the extract is effective against health disorders associated to oxidative stress.
American Psychological Association (APA)
Campisi, Agata& Acquaviva, Rosaria& Bonfanti, Roberta& Raciti, Giuseppina& Amodeo, Andrea& Mastrojeni, Silvana…[et al.]. 2014. Antioxidant Properties of Berberis aetnensis C. Presl (Berberidaceae) Roots Extract and Protective Effects on Astroglial Cell Cultures. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1049196
Modern Language Association (MLA)
Campisi, Agata…[et al.]. Antioxidant Properties of Berberis aetnensis C. Presl (Berberidaceae) Roots Extract and Protective Effects on Astroglial Cell Cultures. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1049196
American Medical Association (AMA)
Campisi, Agata& Acquaviva, Rosaria& Bonfanti, Roberta& Raciti, Giuseppina& Amodeo, Andrea& Mastrojeni, Silvana…[et al.]. Antioxidant Properties of Berberis aetnensis C. Presl (Berberidaceae) Roots Extract and Protective Effects on Astroglial Cell Cultures. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1049196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049196