The Role of IL-33 in Host Response to Candida albicans
Joint Authors
Rodriguez-Cerdeira, Carmen
Lopez-Bárcenas, A.
Sánchez-Blanco, B.
Arenas, R.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Interleukin (IL) 33 is a recently identified pleiotropic cytokine that influences the activity of multiple cell types and orchestrates complex innate and adaptive immune responses.
Methods.
We performed an extensive review of the literature published between 2005 and 2013 on IL-33 and related cytokines, their functions, and their regulation of the immune system following Candida albicans colonization.
Our literature review included cross-references from retrieved articles and specific data from our own studies.
Results.
IL-33 (IL-1F11) is a recently identified member of the IL-1 family of cytokines.
Accumulating evidence suggests a pivotal role of the IL-33/ST2 axis in host immune defense against fungal pathogens, including C.
albicans.
IL-33 induces a Th2-type inflammatory response and activates both innate and adaptive immunity.
Studies in animal models have shown that Th2 inflammatory responses have a beneficial role in immunity against gastrointestinal and systemic infections by Candida spp.
Conclusions.
This review summarizes the most important clinical studies and case reports describing the beneficial role of IL-33 in immunity and host defense mechanisms against pathogenic fungi.
The finding that the IL-33/ST2 axis is involved in therapeutic target has implications for the prevention and treatment of inflammatory diseases, including acute or chronic candidiasis.
American Psychological Association (APA)
Rodriguez-Cerdeira, Carmen& Lopez-Bárcenas, A.& Sánchez-Blanco, B.& Arenas, R.. 2014. The Role of IL-33 in Host Response to Candida albicans. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1049245
Modern Language Association (MLA)
Rodriguez-Cerdeira, Carmen…[et al.]. The Role of IL-33 in Host Response to Candida albicans. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1049245
American Medical Association (AMA)
Rodriguez-Cerdeira, Carmen& Lopez-Bárcenas, A.& Sánchez-Blanco, B.& Arenas, R.. The Role of IL-33 in Host Response to Candida albicans. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1049245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049245