Antibacterial Activity of Mulinum spinosum Extracts against Slime-Producing Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Isolated from Nasal Carriers
Joint Authors
Tonn, Carlos
Daniela, Echenique
Alejandra, Chiaramello
Pedro, Rossomando
Claudia, Mattana
Lucía, Alcaráz
Analía, Laciar
Sara, Satorres
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Nasal carriers of Staphylococcus aureus are important reservoirs with risk of developing endogenous infections or transmitting infections to susceptible individuals.
Methicillin-resistant S.
aureus (MRSA) are associated with higher rates of treatment failure.
Some strains of S.
aureus produce slime which is believed to make the microorganisms more resistant to antibiotics and host defenses.
The antibacterial activity of ethyl acetate : n-hexane (EtOAc : HEX) extracts of Mulinum spinosum (5 : 95% EtOAc : HEX, 50 : 50% EtOAc : HEX, 70 : 30% EtOAc : HEX and mix 20 : 80/30 : 70% EtOAc : HEX, 50 : 50/70 : 30/100 : 0% EtOAc : HEX) were assayed against 3 slime-producing S.
aureus strains and 2 MRSA strains isolated from nasal carriers.
S.
aureus ATCC 35556 slime-producing strain and MRSA ATCC 43300 strain were used as controls.
The extracts were prepared using flash chromatography.
M.
spinosum 5 : 95% AcOEt : HEX showed antibacterial effect against all slime-producing strains (MIC: 500 µg/mL) and the highest activity against MRSA strains (MIC: 500 to 1000 µg/mL).
All M.
spinosum extracts assayed were active against slime-producing S.
aureus and MRSA at doses between 500 and 4000 µg/mL.
Both, slime-producing S.
aureus and MRSA are highly contagious and hardly eradicated by antibiotic therapies.
So, there is an increasing need to find new substances with the ability to inhibit these strains.
American Psychological Association (APA)
Daniela, Echenique& Alejandra, Chiaramello& Pedro, Rossomando& Claudia, Mattana& Lucía, Alcaráz& Tonn, Carlos…[et al.]. 2014. Antibacterial Activity of Mulinum spinosum Extracts against Slime-Producing Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Isolated from Nasal Carriers. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1049257
Modern Language Association (MLA)
Daniela, Echenique…[et al.]. Antibacterial Activity of Mulinum spinosum Extracts against Slime-Producing Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Isolated from Nasal Carriers. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1049257
American Medical Association (AMA)
Daniela, Echenique& Alejandra, Chiaramello& Pedro, Rossomando& Claudia, Mattana& Lucía, Alcaráz& Tonn, Carlos…[et al.]. Antibacterial Activity of Mulinum spinosum Extracts against Slime-Producing Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Isolated from Nasal Carriers. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1049257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049257